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seafsee
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 Posted: Tue Nov 13, 2007 9:18 am Post subject: ScienceDaily: Targeted Treatment Strategies For Lupus.... |
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ScienceDaily: Targeted Treatment Strategies For Lupus Suggested By Research
Wake Forest University Baptist Medical Center (2007, November 12). Targeted Treatment Strategies For Lupus Suggested By Research. ScienceDaily. Retrieved November 12, 2007, from
http://www.sciencedaily.com/releases/2007/11/071111182525.htm
Adapted from materials provided by Wake Forest University Baptist Medical Center.
http://www.wfubmc.edu/
| Quote: |
ScienceDaily (Nov. 12, 2007) — New research provides clues about the causes of lupus symptoms and suggests specific new targeted treatment strategies, according to Nilamadham Mishra, M.D., from Wake Forest University Baptist Medical Center, in presentations at the American College of Rheumatology in Boston.
The studies looked at premature atherosclerosis in lupus patients as well as accelerated cell death that seems to be behind many of the disease's symptoms. Lupus is an autoimmune disorder that can involve the joints, kidneys, heart, lungs, brain and blood. An estimated two million Americans have a form of lupus.
[snip]
Previous research by Mishra found that a new class of drugs being developed (histone deacetylase inhibitors) were effective at preventing atherosclerosis in mice prone to develop the disease. In the current study, Mishra and colleagues explored whether it is a specific histone deacetylase, number 9 (HDAC9), that causes the problem.
Histones are considered the master regulators in gene expression, and Mishra was the first to establish an association between abnormal histone codes and the complications of lupus in a mouse model of lupus.
[snip]
Co-researchers on the projects were: John Parks, Ph.D., Eric Olson, Ph.D., and Richard St. Clair, Ph.D., all with Wake Forest, and Kerri Keiger, Ph.D., and Emmanuel Labourier, Ph.D., both with Ambion Inc. in Austin, Tex. |
Other Related Articles
- Drug May Fight Lupus And Atherosclerosis Simultaneously (Nov. 21, 2005)
http://www.sciencedaily.com/releases/2005/11/051121103337.htm
- Vaccine-like Treatment Shows Promise For Fighting Lupus (Oct. 3, 2007)
http://www.sciencedaily.com/releases/2007/10/071001094959.htm
- Fish Oil May Be Good Supplemental Treatment For Lupus, Study Suggests (Nov. 11, 2007)
http://www.sciencedaily.com/releases/2007/11/071109202954.htm
- New Research Suggests Therapeutic Approach For Autoimmune Diseases (May 4, 2004)
Adapted from materials provided by Jackson Laboratory.
http://www.jax.org/
Jackson Laboratory (2004, May 4). New Research Suggests Therapeutic Approach For Autoimmune Diseases. ScienceDaily. Retrieved November 13, 2007, from
http://www.sciencedaily.com/releases/2004/05/040504063845.htm
- Arteries Clog Earlier In People With Lupus, Says New Study (Dec. 22, 2003)
http://www.sciencedaily.com/releases/2003/12/031219073140.htm
{Funding for this study was also provided by the National Heart, Lung, and Blood Institute and the National Center on Minority Health and Health Disparities, which along with NIAMS are parts of the Department of Health and Human Services' (DHHS) National Institutes of Health; DHHS' Public Health Service; the Mary Kirkland Center for Lupus Research at the Hospital for Special Surgery; and the Bugher Foundation.}
Adapted from materials provided by NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases.
http://www.niams.nih.gov/
- Autoantibodies Precede Disease In Lupus Patients (Nov. 6, 2003)
NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases (2003, November 6). Autoantibodies Precede Disease In Lupus Patients. ScienceDaily. Retrieved November 13, 2007, from
http://www.sciencedaily.com/releases/2003/11/031106051118.htm
Arbuckle M, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. NEJM 2003;349(16):1526-33.
Adapted from materials provided by NIH/National Institute Of Arthritis And Musculoskeletal And Skin Diseases.
http://www.nih.gov/niams
- Genetic 'Signature' Linked To Severe Lupus Symptoms (Feb. 12, 2003)
http://www.sciencedaily.com/releases/2003/02/030212071708.htm
- Lupus Brain Damage Pathway Illuminated (Nov. 23, 2001)
http://www.sciencedaily.com/releases/2001/11/011120043704.htm
The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the Department of Health and Human Services' National Institutes of Health, is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases.
For more information about NIAMS, call the information clearinghouse at 301-495-4484 or 877-22-NIAMS (free call) or visit the NIAMS Web site at http://www.niams.nih.gov/
Know anyone with Lupus?
Chances are you do and aren't aware of it. This disease seems to be hereditary, so you may actually know more than just one person suffering from Lupus.
Here's a good starting point in understanding what Lupus is, where to get help and some articles about promising research.
If anyone is aware of a Distributed Computing model or program assisting in researching Lupus, please let us know.
If you're aware of other material about Lupus, such as dietary or new breakthroughs, please reply to this and add this information.
Thanks,
Charlies Web
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